Yes. You can block ads by creating a special script, you can find the info on how to do that at the end of this GitHub ticket but I’ll paste it here too.

1. Navigate to the uBlock Origin Dashboard (the extension options)

2. Under the My filters tab add twitch.tv##+js(twitch-videoad).

3. Under the Settings tab, enable I am an advanced user, then click the cog that appears.

4. Modify the value of userResourcesLocation from unset to the URL https://github.com/pixeltris/TwitchAdSolutions/raw/master/vaft/vaft-ublock-origin.js

Then just disable and reenable uBlock to refresh it and you should be good to go.

My AdBlocker still works on twitch, you just have to do some fanaegling with user scripts.

Oh no! Anyway…

continues using an AdBlocker